The NFL Week 4 schedule features several games that could have a big impact on early-season division, and conference races.
Which teams will take advantage of their opportunities and emerge with victories?
Check out The Arizona Republic's picks and predictions for each game on the NFL Week 4 schedule.
Click on each game for picks and predictions for that game from other sites. All times MST.
NFL Week 4 odds:
- Dolphins vs. Bengals | Vikings vs. Saints | Browns vs. Falcons
- Bills vs. Ravens | Commanders vs. Cowboys | Titans vs. Colts
- Seahawks vs. Lions | Chargers vs. Texans | Bears vs. Giants
- Jaguars vs. Eagles | Jets vs. Steelers | Cardinals vs. Panthers
- Patriots vs. Packers | Broncos vs. Raiders | Chiefs vs. Bucs
- Rams vs. 49ers | Spreads, lines, over/unders| Super Bowl
Thursday Night Football schedule
Miami Dolphins vs. Cincinnati Bengals, 5:15 p.m., Amazon Prime
The Dolphins are the AFC's lone unbeaten team three weeks into the season. They won't be unbeaten after their Week 4 game against the Bengals.
Prediction: Bengals 31, Dolphins 27
NFL Week 4 picks, predictions:
- Dolphins vs. Bengals | Vikings vs. Saints | Browns vs. Falcons
- Bills vs. Ravens | Commanders vs. Cowboys | Titans vs. Colts
- Seahawks vs. Lions | Chargers vs. Texans | Bears vs. Giants
- Jaguars vs. Eagles | Jets vs. Steelers | Cardinals vs. Panthers
- Patriots vs. Packers | Broncos vs. Raiders | Chiefs vs. Bucs
- Rams vs. 49ers | The Republic's Week 4 NFL predictions
Sunday early football games
Minnesota Vikings vs. New Orleans Saints, 6:30 a.m., NFL Network
The Saints have not looked good over the past two weeks, and have scored just 24 total points over that time span. Look for the troubles to continue against the Vikings.
Prediction: Vikings 24, Saints 13
Cleveland Browns vs. Atlanta Falcons, 10 a.m., CBS
The Falcons are just 1-2, but their two losses came by a combined five points. We're thinking Marcus Mariota and company could surprise Cleveland.
Prediction: Falcons 27, Browns 24
Buffalo Bills vs. Baltimore Ravens, 10 a.m., CBS
Both of these teams are 2-1 and expected to be among the final teams remaining in the AFC. Something tells us Buffalo will be pumped for this game after its Week 3 loss.
Prediction: Bills 35, Ravens 28
Washington Commanders vs. Dallas Cowboys, 10 a.m., Fox
Carson Wentz and the Commanders have not impressed early this season, but it wouldn't surprise us to see them knock off the Cowboys after a short week for Dallas.
Prediction: Commanders 27, Cowboys 20
More:NFL power rankings Week 4: Philadelphia Eagles, Miami Dolphins, Jacksonville Jaguars rise
Seattle Seahawks vs. Detroit Lions, 10 a.m., Fox
The Lions are just 1-2 on the season, but they have outscored their opponents 95-93 in their three games. They'll outscore the Seahawks at home in Week 4.
Prediction: Lions 30, Seahawks 20
Los Angeles Chargers vs. Houston Texans, 10 a.m., CBS
Call us crazy, but with Justin Herbert not being 100%, we think the Texans can spring the big upset on the Chargers.
Prediction: Texans 24, Chargers 21
Tennessee Titans vs. Indianapolis Colts, 10 a.m., Fox
Both of these teams got much-needed wins in Week 3 and both need a win in Week 4 to keep pace in the division. We'll take the home team here, just barely.
Prediction: Colts 28, Titans 27
Chicago Bears vs. New York Giants, 10 a.m., Fox
We're still not sure about either of these team's long term chances this season, but they are off to good starts. Saquon Barkley will be the difference at home.
Prediction: Giants 21, Bears 17
Jacksonville Jaguars vs. Philadelphia Eagles, 10 a.m., CBS
The Jaguars have been very impressive so far this season, but the Eagles' defense will be able to slow down Trevor Lawrence and company in Philadelphia.
Prediction: Eagles 31, Jaguars 21
New York Jets vs. Pittsburgh Steelers, 10 a.m., CBS
The Steelers can't start 1-3, right? We'll take Pittsburgh at home, although we're not exactly confident in the pick.
Prediction: Steelers 24, Jets 21
More:NFL Week 4 schedule, television information: How to watch Week 4 NFL games
Sunday late football games
Arizona Cardinals vs. Carolina Panthers, 1:05 p.m., Fox
The Cardinals can't afford to fall to 1-3 on the season. They won't behind a solid performance from Kyler Murray on the road.
Prediction: Cardinals 28, Panthers 20
New England Patriots vs. Green Bay Packers, 1:25 p.m., CBS
The Patriots have not impressed and are now dealing with an injured Mac Jones. Sounds like a recipe for a Green Bay win at home.
Prediction: Packers 30, Patriots 16
Denver Broncos vs. Las Vegas Raiders, 1:25 p.m., CBS
The Raiders can't start 0-4, right? They'll break through for their first win at home in an important division game against Denver.
Prediction: Raiders 31, Broncos 24
More:Super Bowl 57 odds: Betting odds for every NFL team to win 2022-2023 Super Bowl
Sunday Night Football schedule
Kansas City Chiefs vs. Tampa Bay Buccaneers, 5:20 p.m., NBC
The winner of this game moves to 3-1. The loser falls to 2-2 and loses its second straight game. We'll take the road team getting revenge for its Super Bowl 55 loss in this one.
Prediction: Chiefs 24, Buccaneers 20
Monday Night Football schedule
Los Angeles Rams vs. San Francisco 49ers, 5:15 p.m., ESPN, ESPN2
The Rams appear to have righted the ship with consecutive wins after their Week 1 loss. The 49ers somehow lost an 11-10 game in Denver in Week 3. San Francisco will find a way to rebound at home in a sloppy game.
Prediction: 49ers 20, Rams 17
More:NFL Week 4 odds: Point spreads, moneylines, over/under for every Week 4 NFL game
Reach Jeremy Cluffat jeremy.cluff@arizonarepublic.com.Follow him on Twitter @Jeremy_Cluff.
